439例慢性细菌性前列腺炎细菌培养及药敏结果分析

Analysis of bacterial culture and drug sensitivity tests in 439 patients with chronic bacterial prostatitis

目的了解引起慢性细菌性前列腺炎的细菌种类及其体外药敏结果,为临床诊断和治疗前列腺炎提供依据。方法对439例慢性细菌性前列腺炎患者的前列腺液进行细菌培养及体外药敏试验,并对结果进行分析。结果 439例患者共培养出致病菌492株,其中革兰阳性球菌占85.8%,以金黄色葡萄球菌为主;革兰阴性杆菌占14.2%,以大肠埃希菌为主。体外药敏检测结果显示,革兰阳性球菌对左氧氟沙星、青霉素等均有较高的耐药性,对强力霉素、万古霉素最敏感。革兰阴性杆菌对氨苄西林/舒巴坦、阿莫西林耐药性最高,对亚胺培南最敏感。结论慢性细菌性前列腺炎主要是革兰阳性球菌感染,对常用的抗生素有较高的耐药性,应加强对其耐药性的监测,根据药敏结果选用有效的抗生素,以提高疗效和防止耐药菌株的产生。

Objective To investigate the relationship between the bacterial species causing chronic prostatitis and their drug resistance,so as to provide the basis for the clinical diagnosis and treatment of chronic bacterium prostatitis.Methods Bacteria cells were separated and cultured from prostatic fluids of 439 patients for drug sensitivity test.Results Results of bacterium culture：a total of 492 strains of bacteris were isolated from 439 prostatic fluids.Among these strains,Gram-positive coccus were accounted for 85.8% and most of them was staphylococcus aureus,while Gram-negative bacillus were accounted for 14.2% and most of them was E.Coli.Results of drug sensitivity tests：Gram-positive coccus had high drugs resistance to levofloxacin or penicillin and were sensitive to vancomycin or doxycycline,and Gram-negative bacillus had high drug resistance to ampicillin/sulbactam or amoxicillin,which sensitive to imipenem.Conclusion The main pathogenic species of chronic bacterial prostatitis were Gram-positive coccus,and the common antibiotics resistance rate is rather high,of which the surveillance for drug resistance should be emphasized.Antibiotics selection should based on drug sensitivity test for improving therpeutic effects and reducing the production of drug resistant strains.