染色体罗伯逊易位女性携带者对控制性超排卵的卵巢反应

Ovarian Responsiveness of Female Robertsonian Translocation Carriers in Controlled Ovarian Hyperstimulation

目的:初步探讨罗伯逊易位对控制性超促排卵(COH)中卵巢反应性的影响。方法:回顾性分析12个周期针对罗伯逊易位不孕夫妇行胚胎植入前遗传学诊断(PGD)的COH方案,其中女性罗伯逊易位携带者(研究组)5个周期,男性罗伯逊易位携带者(对照组)7个周期。比较分析患者年龄、体质量指数(BMI)、基础内分泌及COH中降调节天数、Gn使用天数、Gn用量、hCG注射日E2值、获卵数、2PN受精率、2PN卵裂率、移植胚胎数等。结果:年龄、BMI、基础内分泌及COH中降调节天数、Gn使用天数、2PN受精率、2PN卵裂率、移植胚胎数及获卵数组间无统计学差异,但研究组的Gn用量(3 128.6±891.3 IU)明显高于对照组(1 810.0±630.9 IU)(P<0.05);研究组hCG注射日E2值为3 233.8±1 938.2 pg/ml,明显低于对照组的8 143.6±1 926.3 pg/ml(P<0.05)。结论:染色体罗伯逊易位影响卵巢对COH的反应性。

Objective：To evaluate the effect of Robertsonian translocations on ovarian responsiveness in controlled ovarian hyperstimulation（COH） for the couples having Robertsonian translocations.Methods： In this retrospective study,12 cycles of COH in preimplantation genetic diagnosis（PGD） for Robertsonian translocations were reviewed including 5 cycles for female carriers（study group） and 7 cycles for male carriers（control group）.Results： There was no significant difference in age,body mass index（BMI）,basal FSH/LH/E2 level,number of down-regulation days,number of days of Gn stimulation,number of oocytes retrieved,2PN fertilization rate,2PN cleav-age rate,number of ETs between the two groups.However,total doses of Gn in the study group was higher than that in the control（3 128.6±891.3 IU vs 1 810.0±630.9 IU,P〈0.05）.E2 level on the day of hCG injection of study group was lower than that of the control（3 233.8±1 938.2 pg/ml vs 8 143.6±1 026.3 pg/ml,P〉0.05）.Conclusion： Female Robertsonian translocations is associated with a reduced ovarian responsiveness to gonadotropins.