反义RNA转录——基因表达调控的一种表观遗传学机制

Antisense RNA Transcription:An Epigenetic Mechanism for Gene Expressions Regulation

反义RNA(antisense RNA,AS-RNA)是一种存在于细胞内的非编码RNA,反义转录在哺乳动物基因组中广泛存在,可能在基因表达的相关调控机制中起着重要作用。目前研究发现,ASRNA主要是通过表观遗传学上的改变,对基因进行调控。DNA甲基化水平的改变,组蛋白修饰引起的染色质构型重塑,以及其它非编码RNA的调控作用均与AS-RNA有着密切的关系。

Antisense RNA （AS-RNA） is a kind of non-coding RNA. Antisense transcription is a widespread phenomenon in the mammalian genome. It is thought to play a role in regulation of gene expression. Recent study confirmed that antisense RNA medicated gene-expression mainly through epigenetic mechanism. The changes of the level of DNA methylation, heterochromatin formation by the histone modification and other non-coding RNA interferences might be related to antisense RNA.