期刊文献+

肝纤维化的治疗进展 被引量:2

The advances of antifibrosis treatment
原文传递
导出
摘要 肝纤维化是多种慢性肝病的共同病理基础,表现为肝脏细胞外基质合成增多,降解减少。近年来肝纤维化的研究有两大进展:一是纤维化发生机制的研究,特别是干细胞和上皮一间质细胞转分化扩展了肝星状细胞(HSC)的可能来源;二是肝纤维化无创评价指标的建立,随着肝脏弹性硬度检测等手段的完善,对临床抗肝纤维化的药物治疗也有了更好的手段进行监测和评价。
作者 尤红 吴鹏
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2010年第8期574-575,共2页 Chinese Journal of Hepatology
关键词 肝硬化 治疗学 临床试验 Liver cirrhosis Therapeutics Clinical trials
  • 相关文献

参考文献8

  • 1Wang P,Liu T,Cong M,et al.Expression of extracellular matrix genes in cultured hepatic oval cells:an origin of hepatic stellate cells through transforming growth factor beta? Liver Int,2009,29:575-584.
  • 2Chan HL,Wong GL,Choi PC,et al.Alanine aminotransferase-based algorithms of liver stiffness measurement by transient elastography (Fibroscan) for liver fibrosis in chronic hepatitis B.J Viral Hepat,2009,16:36-44.
  • 3Popov Y,Schuppan D.Targeting liver fibrosis:strategies for development and validation of antifibrotic therapies.Hepatology,2009,50:1294-1306.
  • 4Gish RG.Improving outcomes for patients with chronic hepatitis B.Curr Gastroenterol Rep,2007,9:14-22.
  • 5Maylin S,Martinot-Peignoux M,Moucari R,et al.Eradication of hepatitis C virus in patients successfully treated for chronic hepatitis C.Gastroenterology,2008,135:821-829.
  • 6Talwalkar JA.Antifibrotic therapies--emerging biomarkers as treatment end points.Nat Rev Gastroenterol Hepatol,2010,7:59-61.
  • 7Ghiassi-Nejad Z,Friedman SL.Advances in antifibrotic therapy.Expert Rev Gastroenterol Hepatol,2008,2:803-816.
  • 8Garcia-Tsao G,Friedman S,Iredale J,et al.Now there are many (stages) where before there was one:In search of a pathophysiological classification of cirrhosis.Hepatology,2010,51:1445-1449.

同被引文献45

引证文献2

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部