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有机小分子催化的β-酮酯不对称α-官能化反应 被引量：1

Organocatalytic Asymmetric α-Functionalization of β-Ketoesters
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摘要 有机小分子催化的不对称反应是目前有机化学的研究热点之一。β-酮酯是一类具有活泼次甲基的"软"亲核试剂,可以在有机碱或者金属路易斯酸的催化下进行α-官能化反应。本文详细介绍了有机催化的β-酮酯不对称α-官能化反应的最新研究进展,并对不同亲电试剂参与β-酮酯的α-官能化反应进行了简要评述。 Asymmetric organocatalysis has attracted a considerable amount attention for organic chemists. Due to the α-acidic hydrogen, β-ketoesters could be functionalized in the presence of organic base or metal Lewis acid. Recent development of organocatalytic asymmetric α-functionalization of β-ketoesters reactions is reviewed, and various electrophiles of these reactions are described.
作者 方玲 石岩 朱成建
机构地区 南京大学化学化工学院
出处 《化学进展》 SCIE CAS CSCD 北大核心 2010年第9期1679-1686,共8页 Progress in Chemistry
关键词 不对称合成 有机催化 β-酮酯 α-官能化反应 asymmetric synthesis organocatalysis β-ketoesters α-functionalization
分类号 O621.251 [理学—有机化学] O621.34 [理学—有机化学]
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参考文献77

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同被引文献10

  • 1Faye Maertens, Suzanne teppet, Frans compemolle. Incorporation of diarylbutylamine pharmacophore into indeno- or naphtho [ 1,2-b ] pyran Ring Systems [ J ]. Eur J Org Chem,2004:2707-2714.
  • 2Eugene G, Tamar Y, Alfred H. Utilization of ethyl 2-[(phenylsulfonyl) methyl ] acrylate for the synthesis of a-methylenevaIerolactones [ J ]. J Org Chem, 1990, 55 (24) :5977 -5982.
  • 3Carlos A M Fraga, Lis Helena P Teixeira, Carla Mafia de S Menezes, et al. Studies on diastereoselective re- duction of cyclic β-ketoesters with boron hydrides. Part 4:The reductive profile of functionalized cyclohexanone derivatives [ J ]. Tetrahedron,2004,60: 2745 - 2755.
  • 4Cui H L, Peng J, Chen Y C. etal. Dual organocatalysis : Asymmetric anylic-allylic alkylation of a, a-dicyanoalkenes and Morita-Baylis-Hilhnan carbonates [J].Chem Eur J,2009,15 : 1574 - 1577.
  • 5Peng J, Huang X, Chen Y C. Organocatalytic and electrophilic approach to oxindoles with C3-quaternary stereocenters [ J ]. Org Lett, 2010, 12 ( 19 ) : 4260 - 4263.
  • 6House H O, Hudson C B. Perhysro indan derivatives Ⅻ6-Methoxyindanone and its derivatives [ J]. J Org Chem, 1970,35 ( 8 ) : 647 - 651.
  • 7Jack K Crandall, Chrostian Pradat. Synthesis of Sulfones by phase-transfer alkylation of arenesulfinate salts[J]. J Org Chem,1985,50(8) :1327 - 1329.
  • 8Feng J, Lu X, Kong A, etal. A highly regio- and stero-selective [ 3 + 2 ] annulation of allylic com- pounds and 2-substituted 1,1-dicyanoalkenes through a catalytic carbo-phosphorus ylid reaction[ J ]. Tetra- hedron,2007,63:6035 - 6041.
  • 9D Y S, Hart X L, Lu X Y. Alkaloids-catalyzed regio- and enant/o-se]ectlve allylic nucleophilic substitution of tert-butyl carbonate of the Morit-Bayllc-Hillman products [ J ]. Tetrahedron Left, 2004, 45: 4967 - 4971.
  • 10PENG Jing,CUI HaiLei & CHEN YingChun Key Laboratory of Drug-Targeting and Drug Delivery System,Ministry of Education,Department of Medicinal Chemistry,West China School of Pharmacy,Sichuan University,Chengdu 610041,China.Organocatalytic asymmetric allylic alkylation of sulfonylimidates with Morita-Baylis-Hillman carbonates[J].Science China Chemistry,2011,54(1):81-86. 被引量：1

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化学进展
2010年 第9期

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