中药微球介入治疗肿瘤的研究进展

Advances in research of microspheres containing Chinese medicine for interventional cancer therapy

药物微球是近年来利用微球化技术发展的药物新剂型,将微球制剂应用于中药可以弥补传统剂型的缺陷,提高生物利用度,降低药物使用剂量和非靶部位的毒性,使其具有缓释和靶向特性,因此中药微球已成为中药新剂型给药系统研究的热点.我们就中药微球的生物学特性、研究现状及存在的问题综述如下.

Drug-loaded microspheres represent a newly developed particulate drug delivery system that possesses the characteristics of controlled release and targeting delivery.The use of microsphere agents in Chinese medicine can make up for the deficiency of traditional preparations,improve bioavailability,and decrease use dosage and non-target toxicity,so it have controlled release and targeting characteristics.Therefore,the research on microsphere agents has become a hot topic in the development of new delivery system for Chinese medicine.In this paper,we will review the biological characteristics of microsphere agents and discuss the recent advances and problems encountered in the research of microsphere agents.