雌激素核外受体和核受体作用的整合

Integration of Extra-nuclear and Nuclear Estrogen Receptor Actions

雌激素受体可位于细胞内很多位置,全面地发挥作用。近年来研究发现,除雌激素核受体(nER)外,有部分雌激素受体位于质膜,还有部分雌激素受体位于细胞质。雌激素核外受体和核受体信号传导可以交互联系。雌激素及其受体在不同细胞位置上作用的整合将产生雌激素的快速和延迟作用,在性器官和其它器官中都发挥着重要的生物学作用。

Estrogen receptors localized to many sites within the cell are giving comprehensive contribution to estrogen functions.In recent years,researches have identified that some estrogen receptors are localized to the plasma membrane,while other estrogen receptors exist in cytoplasm besides nucleus.Cross-talk occurs between extra-nuclear estrogen receptor and nuclear estrogen receptor signalings.The integration of estrogen and its receptor actions from different sites within the cell leads to the rapid and prolonged actions of estrogen,thus they produce important biological functions in the sex organ and other organs.