摘要
目的比较改良超长方案降调节结合人绝经期促性腺激素（HMG）和常规长方案降调节在多囊卵巢综合征（PCOS）不孕患者行体外受精/胞质内单精子注射-胚胎移植术（IVF/ICSI-ET）助孕中的疗效。方法回顾分析我院2008年8月~2009年12月采用改良超长方案的132例和常规长方案588例PCOS患者,对2组受精率、卵裂率、临床妊娠率、着床率、抱婴率、流产率及治疗费用等重要指标进行统计和对比。结果与常规长方案组相比,改良超长方案组患者的受精率、卵裂率、着床率及临床妊娠率显著上升（P〈0.001）;用药天数缩短且患者治疗费用显著减少（P〈0.001）;抱婴率上升、流产率下降（P〈0.05）。结论改良超长方案结合HMG超排卵能有效改善PCOS不孕患者行IVF/ICSI-ET的妊娠结局并节约治疗费用。
Objective To compare and analyze the effect of two controlled ovarian stimulation（COH） protocols（modified ultra-long down-regulation protocol vs conventional long down-regulation protocol） for in vitro fertilization/intracytoplasmic sperm injection-embryo transfer（IVF/ICSI-ET） treatment in infertility patients with polycystic ovarian syndrome（PCOS）.Methods 132 IVF/ICSI-ET cycles utilizing modified ultra-long down-regulation protocol and 588 IVF/ICSI-ET cycles underwent conventional long down-regulation protocol during August 2008 to December 2009 were retrospectively analyzed.Several key parameters of the two COH protocols,including： fertilization and cleavage rate,clinical pregnancy rate,live birth rate,abortion rate,treatment duration and therapeutic expenses etc.were compared and analyzed.Results In modified ultra-long down-regulation protocol,the fertilization and cleavage rate,clinical pregnancy rate and implantation rate were significantly increased（P0.001）,as well for the live birth rate（P0.05）,the abortion rate（P0.05） and the progesterone level on the day of HCG injection were decreased（P0.001）.In the mean while,the treatment duration was shortened（P0.001）,and treatment cost were reduced（P0.001）,when compared to conventional long protocol.Conclusion Modifiedsuper-long protocol plus HMG for PCOS infertile patients saved the therapeutic cost and raised the success rate of ART.
出处
《基础医学与临床》
CSCD
北大核心
2010年第9期984-987,共4页
Basic and Clinical Medicine
基金
国家973专项基金(2007CD948103)
