摘要
本实验用10^(-8)mol/L 内皮素灌流离体大鼠心脏,导致平均灌流压,心室内压急剧升高,±LV dP/dt_(max)值显著降低,心肌蛋白漏出和脂质过氧化物形成,心肌钙含量显著增加等严重心脏功能和组织损伤。钙通道阻滞剂维拉帕米,无论与内皮素同时灌流或在内皮素灌流以后应用,都能有效地拮抗内皮素的心脏损伤作用。
Isolated rat hearts perfused with endothelin at a concentration of 10^(-8)mol/L showed serious functional and celluar myocardial deteriolation as manifestedby a significant increase of mean perfusion and left ventricular pressure,decreaseof±LV dp/dt_(max),leakage of myocardial protein,formation of lipid peroxides,increase of myocardial calcium content,etc.Calcium channel blocker,vera-pamil,effectively antagonized the injurious action of endothelin on rat heartwhether administered along with or after endothelin perfusion.
出处
《生理学报》
CAS
CSCD
北大核心
1990年第4期374-378,共5页
Acta Physiologica Sinica
基金
国家科委资助项目
关键词
心脏损伤
内皮素
钙拮抗剂
endothelin
calcium channel blocker
heart
