摘要
目的了解血清survivin水平与视网膜母细胞瘤发生和发展的关系。方法测定26例视网膜母细胞瘤患者,21例非恶性眼病患者血清中survivin含量,比较2组患者血清中survivin含量,并且比较不同病理分期和临床分期的视网膜母细胞瘤患者血清中survivin水平。利用ROC曲线分析survivin水平,判断survivin的最优截断点并计算灵敏度、特异度、阳性预测值和阴性预测值。结果视网膜母细胞瘤患者组血清survivin水平显著增高(P<0.01),不同病理分期和临床分期的视网膜母细胞瘤患者血清survivin水平差异无统计学意义(P>0.05)。血清survivin水平的ROC曲线下面积为0.886,最优截断点约为15.5 ng/L,灵敏度和特异度为92.3%和81.0%,阳性预测值为85.7%,阴性预测值为89.5%。结论血清survivin水平的检测可以用于对视网膜母细胞瘤的初步诊断,可将其作为视网膜母细胞瘤的辅助检查项目。
Objective To evaluate serum survivin level in retinoblastoma patients.Methods Survivin was measured in 47 serum samples from 26 children with retinoblastoma and 21 children with nonmalignant ophthalmic disease.To compare the survivin level in two groups,different tumor stage groups and different grade tumor groups.The optimal cut-off of serum survivin was identified by using ROC curve.Sensitivity,specificity,positive predictive value and negative predictive value were calculated at optimal cut-off.Results Survivin in retinoblastoma group is higher than that in nonmalignant ophthalmic disease group（P0.01）.There is no significant difference in different tumor stage groups and different grade tumor groups（P0.05）.The AUROC of serum survivin was 0.886,the optimal cut-off value was 15.5 pg/L.Sensitivity and specificity were 92.3% and 81.0%,and positive predictive value and negative predictive value were 85.7% and 89.5%,respectively.Conclusion Serum survivin may have a great diagnostic potential in retinoblastoma.
