西宁地区丙泊酚对凝血功能的影响

The Effects of Propofol on Blood Coagulation in Xining Region

目的:观察西宁地区丙泊酚对凝血功能的影响。方法:选择ASA(Ⅰ～Ⅱ)级择期行腹腔镜下胆囊切除手术患者60例,分别于麻醉前(T0)、麻醉插管前(T1)、手术开始前(T2)、手术开始30分钟后(T3)、停用丙泊酚1小时后(T4)采血测定血小板最大聚集率和血小板计数、凝血酶原时间(PT)、凝血酶时间(TT)、部分凝血酶时间(APTT)。结果:血小板最大聚集率T1、T2与T0相比,血小板聚集功能明显受到抑制,差异有显著性(P<0.05),T3、T4与T0相比无明显变化(P>0.05),血小板计数及其他凝血参数T1、T2、T3、T4与T0相比无显著性改变(P>0.05)。结论:西宁地区应用丙泊酚对凝血功能无明显影响,但对长时间大剂量输注丙泊酚的病人宜慎重。

Objective：To observe the effects of propofol on blood coagulation in Xining region.Methods：60 patients （male 30,female 30; aged 26-51 years）,who would receive laparoscopic cholecystectomy under general anesthesia （propofol,sufentanil,and vecuronium,Intravenous drip ） and who had normal BP,Liver and kidney function and coagulation,were selected in this report. The maximum platelet aggregation and platelet count,prothrombin time （PT）,thrombin time （TT）,partial thromboplastin time （APTT） were determined before anesthesia （T0 group）,intubation （T1 group）,surgery （T2 group）,after 30 minutes surgery （T3 group） and suspension after 1 hour of propofol （T4 group） respectively.Results： The maximum aggregation rate of platelets in T1 and T2 group were significantly decreased as compared with the T0 group （P0.05）. There was no a difference in maximum platelet aggregation between T3 or T4 and T0 group （P0.05）; as compared with T0,no difference in platelet count,PT,TT and APTT in other group （P0.05）.Conclusions： There is a less effect of propofol on blood coagulation under general anesthesia condition in Xining area,but use of propofol at a long period and large dose would be careful.