糖耐量减低患者的转归及影响因素的Logistic多元回归分析

Multivariate logistic regression analysis for outcome and risk factors of impaired glucose tolerance patients

目的观察糖耐量减低(IGT)患者中糖尿病发生率及其危险因素。方法收集2005至2006年糖耐量减低患者355例,随机分为干预治疗组(n=166)和非干预治疗组(n=189),出院后随访3a,统计糖尿病(DM)发生率,用Logistic多元回归分析其危险因素。结果非干预治疗组中发生DM 70例(37.0%),年转化率为12.3%;干预治疗组中发生DM 24例(14.4%),年转化率为4.8%;两组比较差异有统计学意义(P<0.05)。糖尿病发病的危险因素主要与餐后2h血糖(OR=3.016)、家族史(OR=1.446)和年龄(OR=1.176)有关。结论 IGT患者发生DM的主要危险因素为餐后2h血糖、家族史和年龄,早期干预可明显降低DM发生率。

Objective To observe the incidence and risk factors of diabetes mellitus （DM） in patients with impaired glucose tolerance （IGT）. Methods A total of 355 IGT patients enrolled from 2005 to 2006 were randomly divided into control group （n=189） and treatment group （n=166）, and the incidence and risk factors of DM in both groups were analyzed by multivariate logistic regres-sion an- alysis within 3-year followed-up. Results The incidence and annual conversion rate of DM were 37.0% and 12.3% in control group, and 14.4% and 4.8% in treatment group, respectively; there were statistical differences between both groups （P〈0.05）. The risk factors of DM were 2h blood glucose （OR=3.016）, diabetes family history （OR=1.446） and age （OR=1.176）. Conclusion The risk factors of DM include 2h blood glucose, diabetes family history and age, and early intervention may improve the prevalence of DM in IGT patients.