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跟踪红细胞生成刺激剂与铁代谢新进展,指导慢性肾脏病贫血治疗 被引量：2

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摘要 贫血是慢性。肾脏病（chronic kidney disease，CKD）尤其是透析患者主要并发症之一。近年研究表明，贫血常常使患者生活质量下降，心血管疾病发病率和死亡率明显增加。肾性贫血的有效治疗，对减少CKD患者心血管事件、改善患者脑功能和机体活动能力，提高生活质量，降低患者住院率和死亡率都十分重要。
作者 郑法雷 袁群生
机构地区 中国医学科学院北京协和医院肾内科
出处 《中国血液净化》 2010年第9期465-466,共2页 Chinese Journal of Blood Purification
关键词 慢性肾脏病 肾性贫血 有效治疗 红细胞生成 铁代谢 刺激剂 透析患者 心血管事件
分类号 R692.5 [医药卫生—泌尿科学]
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参考文献9

  • 1Locatelli F, Nissenson AR, Barrett BJ, et al. Clinical practice guidelines for anemia in chronic kidney disease: Problems and solutions. A position statement from Kidney Disease: Improving Global Outcomes(KD100)[J]. Kidney International, 2008,74:1237-1240.
  • 2Thorp ML, Johnson ES, Yang X, et al. Effect of anaemia on mortality, cardiovascular hospitalizations and end-stage renal disease among patients with chronic kidney disease [J]. Nephrology (Carlton), 2008,14:240-246.
  • 3Foley RN. Emerging erythropoiesis-stimulating agents. Nat Rev Nephrol, 2010,6:218-223.
  • 4徐潇漪,谌贻璞.新型红细胞生成刺激剂的现状与展望[J].中国血液净化,2010,9(9):467-470. 被引量：5
  • 5Singh AK. What is causing the mortality in treating the anemia of chronic kidney disease: erythropoietin dose or hemoglobin level[J]? Curr Opin Nephrol Hypertens, 2010, 19:420-424.
  • 6孙雪峰.正确掌握红细胞生成刺激剂治疗慢性肾脏病贫血的规范[J].中国血液净化,2010,9(9):470-472. 被引量：5
  • 7Macdougall IC. Iron supplementation in the non-dialysis chronic kidney disease (ND-CKD) patient:Oral or intravenous? [J]. Curt Med Res Opin, 2010,26:473-82.
  • 8Anderson GJ, Frazer DM, McLaren GD. Iron absorption and metabolism[J]. Curt Opin Gastroenterol, 2009,25:129-135.
  • 9袁群生,刘鹏举,郑法雷.铁调素对慢性肾脏病患者铁代谢的调节作用及其机制[J].中国血液净化,2010,9(9):473-476. 被引量：4

二级参考文献81

  • 1Locatelli F, Nissenson AR, Barrett BJ, et al. Clinical practice guidelines for anemia in chronic kidney disease: problems and solutions. A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)[J]. Kidney lnt, 2008.74:1237- 1240.
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  • 4Go AS, Yang J, Ackerson LM, et al. Hemoglobin level chronic kidney disease, and the risks of death and hospi talization in adults with chronic heart failure: the Ane mia in Chronic Heart Failure: Outcomes and Resource Utili zation (ANCHOR) Study[J]. Circulation, 2006, 113:2713-2723.
  • 5Schiller B, Doss S, E DEC, et al. Costs of managing anemia with erythropoiesis stimulating agents during hemodialysis: a time and motion study[J], Hemodial Int, 2008,12:441- 449.
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  • 7Jaeobs K, Shoemaker C, Rudersdorf R, et al. Isolation and characterization of genomic and cDNA clones of human erythropoietin[J]. Nature, 1985,313:806- 810.
  • 8Eschbach JW, Egrie JC, Downing MR, et al. Correction of the anemia of end stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial[J]. N Eagl J Med, 1987, 316:73- 78.
  • 9Macdougall IC, Gray SJ, Elston O, eta]. Pharmacokinetics of novel erythropoiesis stimulating protein compared with epoetin alfa in dialysis patients[J]. J Am Soc Nephrol, 1999, 10:2392 -2395.
  • 10Bailon P, Pahlke W, Brandt M, et al. CERA (continuous erythropoiesis receptor activator) for the treatment of renal anemia: A new agent with an innovative mechanism of action[J]. Nephrol Dial Transplant, 2003,166 suppl 4.

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中国血液净化
2010年 第9期

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