异丙酚复合芬太尼维持麻醉对脑代谢的影响

The Effect of Propofelfentaynl Intravenous Anesthesia (IVA)onCerebral Metabolism

观察异丙酚复合芬太尼维持麻醉对脑代谢的影响。择期手术病人８例，采用芬太尼、硫贲妥钠、维库溴铵诱导插管，静脉联接Ｇｒａｓｅｂｙ微泵异丙酚８ｍｇ·ｋｇ－１·ｈ－１，芬太尼１μｇ·ｋｇ－１·ｈ－１维持麻醉。连续监测ＭＡＰ、心电图、脉搏氧饱和度和呼气末二氧化碳分压，同步采集动脉血和颈内静脉血作血气分析，计算动－静脉氧含量差（Ｄａ－ｖＯ２）和脑氧摄取率（ＥＲＯ２）。得到如下观察结果：异丙酚麻醉维持平稳，Ｄａ－ｖＯ２和ＥＲＯ２在给药３０ｍｉｎ，６０ｍｉｎ，测得值较气管插管后５ｍｉｎ无明显改变，有平均动脉压下降和心动过缓。观察结果表明，异丙酚复合芬太尼维持麻醉。

To evaluate the influence of propofelfentaynl IVAon cerebral metabolism,the anesthesia was induced by fentaynlthiopentonevecuronium and maintained by propofelfentaynlvecuronium in 8patients during ordinary surgery.Arterial and venous blood samples were collected simultaneously through radial artery and internal jugular catheterization.The cerebral arteriovenous differences of oxygen content(Da-vO2)were measured and extracting rate of oxygen(RO2)was calculated.There are no significant differences in Da-vO2and CMRO2between the intubation after 5 min and in 30 min,60 min after anesthesia maintained with propofelfentaynl.There are some advantages during IVAwith propofelfentaynl on cerebral oxygen balance.