双歧三联活菌治疗重症急性胰腺炎的临床疗效观察

Clinical effect study of live combined bifidobacterium,lactobacillus and enterococcus capsules in treatment of severe acute pancreatitis

目的:探讨肠道微生态制剂双歧三联活菌在重症胰腺炎治疗中的临床疗效。方法:将入选的42例患者随机分为治疗组和对照组,各21例,对照组予以常规对症治疗,治疗组在对照组基础上加用双歧三联活菌,比较两组在血淀粉酶、血脂肪酶、血白细胞恢复正常的时间,住院时间,胃肠功能评分以及并发症方面的差异。结果:两组患者血淀粉酶、血脂肪酶恢复正常时间比较,差异无统计学意义;但治疗组在加用双歧三联活菌后血白细胞提前恢复正常、胰腺感染例数下降、住院时间缩短,与对照组比较,差异有统计学意义。结论:双歧三联活菌能改善肠道屏障功能、减少感染等并发症的发生,值得临床进一步研究。

Objective：To observe the clinical effect of intestinal micro-ecological agent （live combined bifidobacterium,lactobacillus and enterococcus capsules） in the treatment of severe acute pancreatitis. Methods：Fourty-two patients with severe pancreatitis were randomized equally into two groups,treatment group and control group.Both groups received standard therapeutics procedures and the control group combined use of live combined bifidobacterium,lactobacillus and ente -rococcus capsules.Compared the difference of the time of blood amylase,serum lipase and blood white cells returning to normal,contrasted the hospital time,the score of gastroenteric function and complications of two groups. Results：There was no difference in the blood amylase and serum lipase level,but the time of white cells returning to normal was shorter than the control group,the same as the hospital time,and the patients of pancreatic infection decreased. Conclusion：Live combined bifidobacterium,lactobacillus and enterococcus capsules can change the intestinal barrier function,ruduce the complications as infection,it is worth further study.