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亚临床动脉粥样硬化患者血液环氧合酶-2水平研究

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摘要 目的:探讨亚临床动脉粥样硬化(AS)患者血浆中环氧合酶Ⅱ(COX-2)的活性和单个核细胞COX-2mRNA的表达水平。方法:分别应用酶联免疫法和逆转录聚合酶链反应(RT-PCR)检测100例亚临床AS患者和40例健康对照血浆COX-2活性与单个核细胞COX-2mRNA表达,并结合临床资料进行分析。结果:亚临床AS组COX-2血浆活性水平[(10.84±3.11)U/L]明显高于正常对照组[(6.97±1.25)U/L],差异有统计学意义(P<0.05);RT-PCR半定量分析发现亚临床AS组血液中单个核细胞COX-2mRNA表达的平均吸光度(0.2448±0.0903)较正常对照组(0.0058±0.0027)显著升高(P<0.01)。结论:COX-2血浆活性水平和COX-2mRNA的表达水平与亚临床AS有明显相关性,检测血浆COX-2活性和COX-2mRNA的表达可作为亚临床AS监测的参考指标。
机构地区 郑州人民医院
出处 《中国当代医药》 2010年第26期74-75,共2页 China Modern Medicine
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