泌尿系多原发癌12例临床分析

A Research for the 12 Clinical Cases of Multiple Primary Cancers Associated with Urologic System

目的探讨泌尿系多原发癌的病因、发病规律、治疗方法和预后。方法回顾性分析12例泌尿系多原发癌的临床资料。结果泌尿系多原发癌的发病率占同期泌尿系肿瘤的0.45%;平均发病年龄为74.6岁;男性10例,女性2例;同时发病4例,异时发病8例;至随访截止之日,存活4例,死亡8例;根治性手术预后较好,术后辅助放疗、化疗、内分泌治疗及生物免疫治疗具有一定疗效。结论泌尿系多原发癌男性发病率高于女性,且年龄越大发病率越高;多原发癌的预后较单原发癌差;积极的手术治疗联合辅助治疗可以提高疗效。

Objective To investigate the etiological factor,incidence,therapies and prognoses of the multiple primary cancers associated with urologic system.Methods The medical records of 12 cases of multiple primary cancers associated with urologic system were studied retrospectively.Results The multiple primary cancers associated with urologic system was 0.45% of the total urologic neoplasms in the corresponding time period.The mean age of onset was 74.6 years.The sex ratio： the male vs the female was 10∶2.There were 4 patients who had the first cancer and the second cancer concurrently in the 12 patients.Surgical removal of tumors was more effective,and actinotherapy,chemotherapy,endocrinotherapy and immunotherapy could improve the curative effection after the operation.Conclusion The male patients with multiple primary cancers associated with urologic system are more than the female patients,and with the age becoming older,an increasing tendency of incidence has been observed.The prognoses of multiple primary cancers are worse,but we can get a better treatment effectiveness by surgical removal of tumors and adjunctive therapy.