连翘叶提取物对实验小鼠的降脂保肝作用研究

Effects of Extracts from Forsythia suspense Leaves on Modulating Blood Lipids and Protecting Liver of Hyperlipidemic Mice

选用ICR健康小鼠,通过复制高脂血症模型,研究连翘叶提取物(extracts fromForsythiasuspenseleaves,FSE)对高脂血症小鼠血液、肝脏指标的影响.结果显示:FSE可降低高脂血症小鼠血清中总胆固醇(total cholester-ol,TC)、甘油三酯(total triglyceride,TG)、低密度脂蛋白(low-density lipoprotein,LDL-C)水平,升高高密度脂蛋白(high-density lipoprotein,HDL-C)水平;此外,FSE还可降低肝脏中TC、丙二醛(malordiaolehyde,MDA)含量,提高超氧化物歧化酶(superoxide dismutase,SOD)活性.以上结果提示,FSE可改善高脂血症小鼠血脂紊乱现象,对其肝脏也具有一定的保护作用.

To study the effects of FSE（extracts from Forsythia suspense leaves）on hyperlipidemic mice,sixty healthy ICR mice were used as copy animal model of hyperlipidemia.Blood lipids,TC and lipid peroxide in liver were measured.The results showed that FSE could reduce the level of serum TC,TG,LDL-C and raise serum HDL-C level.Moreover,FSE also could reduce TC,MDA level and raise SOD activity in liver.FSE could modulate blood lipids and protect the liver of hyperlipidemic mice.