摘要
研究实验分别将0．1％，0．2％，0．3％，0．4％，0．5％和1．0％的口服D-青霉胺混合在膳食成分中让实验大鼠通过摄食自然摄取，旨在寻求一种更为简便和人道的治疗途径，并探讨其有效移除大鼠体内铜元素的最适膳食剂量．实验结果发现0．3％和0．4％D．青霉膳食可以显著地移除大鼠肝脏和血清中的铜元素，而且未发现明显的毒副作用，因此0．3％～0．4％被认为是D-青霉胺最适的膳食剂量．研究结果还表明铜和锌在大鼠肝脏内的代谢途径并不一致．
To establish an easier and more humane treatment way, experimental rats were respectively fed 0. 1% , 0.2% , 0. 3% , 0.4% , 0.5% and 1.0% of D-penicillamine mixing with dietary compositions,and the proper dietary D-penicillamine dose was discussed. The results indicated that the doses of 0.3% and 0.4% of D-penicillamine effectively decreased the copper content in liver and serum of rats through promoting the urinary output of copper without side-effects. Therefore, 0.3% - 0.4% was considered as the best dietary D-penicillamine dose for removing copper from rats. Also, the results showed that the metabolisms of copper and zinc in rats were not exactly similar, and there might he a precise mechanism for maintaining the hepatic zinc lever.
出处
《北京工商大学学报（自然科学版）》
CAS
2010年第4期26-30,共5页
Journal of Beijing Technology and Business University:Natural Science Edition
关键词
D-青霉胺
膳食剂量
大鼠
铜
锌
D-penicillamine
dietary dose
rats
copper
zinc
