乐友与阿米替林对抑郁症的疗效及安全性对照研究

A comparative study on Seroxat and Amitriptylinein treatment patients with depression

目的：比较乐友和阿米替林治疗抑郁症的疗效和安全性。方法：对68例抑郁症患者分别给予乐友、阿米替林治疗8周,采用汉密尔抑郁量表（HAMD）,汉密尔焦虑量表（HAMA）,临床大体印象量表（CGI）,不良反应量表（TESS）在治疗前及治疗后第1、2、4、6、8周末分别评定疗效和不良反应。结果：（1）两组治疗后及治疗前的HAMD、HAMA评分比较,第2~8周末差异有显著性（P〈0.05）。（2）两组治疗后及治疗前的各时点的HAMD、HAMA减分率比较,第2周、第4周减分率有显著性差异（P〈0.05）。（3）两组治疗前后CGI评分,病情严重程度（SI）第2周末有显著性差异（P〈0.05）,疗效总评（GI）以及疗效指数（EI）第4~8周末均有显著性差异（P〈0.05）。（4）TESS评分显示第4~8周末均有显著性差异（P〈0.05）,乐友组不良反应少于阿米替林组。结论：乐友较阿米替林治疗抑郁症疗效相当、起效较快、不良反应较小。

Objective：To explore the efficacy and safety of Seroxat and Amitriptylinein the treatment of depression.Methods：Fifty eight patients with depression were recruited in the study,thirty patients was treated with Seroxat and twenty eight patients with Chlorimipramine.The therapy persisted in eight weeks.Hamilton Depression Rating Scale（HAMD）,Hamilton Anxiety Rating Scale（HAMA）,Clinical Global Impression（CGI） and Treatment Emergent Symptom Scale（TESS） were used for assessment of therapeutic efficacy and side effects.Results：（1） The Scale of HAMD and HAMA of two groups decreased significantly after treatment（P0.05）.（2）The decreasing radio of HAMD and HAMA score between two group was significant different at any time point from the first weekend after treatment（P0.05）.（3） CGI score was significant different（P0.05）.（4）TESS showed Seroxat had less side effects than Chlorimipramine（P0.05）.Conclusions： Seroxat is of good efficacy,rapid action,high safety and less side effects in treating patients with depression.