文拉法辛和氯丙咪嗪治疗抑郁和焦虑共病对照研究

Venlafaxine versus Clomipramine for the treatment of depression and anxiety disorders randomized study

目的:研究文拉法辛和氯丙咪嗪治疗抑郁和焦虑共病的有效性和安全性。方法:随机对照研究,为期10周。以临床判断、HAMA、HAMD等量表评定临床效果,以TESS评定不良反应。结果:入组73例(文拉法辛缓释胶囊38例,氯丙咪嗪35例),因不良反应而退组5例(分别为1例和4例),完成研究者68例(分别为37例和31例)。平均最高剂量为:文拉法辛缓释胶囊163.5 mg/d,氯丙咪嗪159.7 mg/d。疗效判断,文拉法辛缓释胶囊和氯丙咪嗪的显效率分别为62.2%和64.5%,两种药物的效果无显著性差异。不良反应的发生率,文拉法辛缓释胶囊组18.4%,远低于氯丙咪嗪组的42.9%。结论:文拉法辛缓释胶囊是一种疗效好、安全性高的治疗抑郁和焦虑共病的药物。

Objective：To compare the efficacy and safety of Venlafaxine versus Clomipramine in patients with depression and anxiety.Methods：A 10 weeks randomized study was designed.The efficacy was evaluated by clinical judgment.HAMA and HAMD.The safety was assessed in terms of TESS.Results： 73 cases of panic disorder were enrolled and 5 cases were withdrawn due to intolerance of side effects.1 case from group of Venlafaxine and 4 cases from group of Clomipramine.Among complete cases.37 were in the treatment of Venlafaxine and 31 were in clomipramine.According to the judgment of clinicians,the marked improved rate was 62.2% for Venlafaxine and 64.5% for Clomipramine.However there was no significant difference in any efficacy measurement between two groups.Venlafaxine group had much lower incidence of side effect（18.7%） than that of Clomipramine（42.9%）.Conclusions： Venlafaxine is one of efficient and high-safety drug in treatment of depression and anxiety.