阿立哌唑与氯氮平治疗慢性精神分裂症对照研究

A comparative study on Aripiprazole versus Clozapine in the treatment of chronic schizophrenia

目的:比较阿立哌唑与氯氮平治疗慢性精神分裂症患者的临床疗效及安全性。方法:80例慢性精神分裂症患者随机分成研究组和对照组各40例,分别予以阿立哌唑及氯氮平治疗8周,采用阳性与阴性症状量表(PANSS)评定临床疗效,不良反应量表(TESS)评定不良反应。结果:治疗8周后阿立哌唑和氯氮平显效率分别为70%和72.5%,二者疗效相当,差异无显著性(P>0.05),不良反应发生率阿立哌唑47.5%,氯氮平77.5%,二者比较差异有显著性(P<0.05)。结论:阿立哌唑治疗慢性精神分裂症有疗效好,不良反应少,安全性高的特点。

Objective：To compare the efficacy and safety between Aipirazole and Clozapine in the treatment of chronic schizophrenia.Methods：80 patients with chronic schizophrenia were randomly divided into study group（n=40） and control group（n=40）,treated with Aripiprazole and Clozapine respectively for 8 weeks.The positive and negative symptom scale（PANSS） and treatment emergent symptom scale（TESS） were used to assess the therapeutic efficacy and side effect respectively.Results： Aripiprazole was as effective as Clozapine for the treatment of chronic schizophrenia（P0.05）.The marked improvement rate of the former was 70% and the later was 72.5%.The incidence rate of adverse effect was 47.5% in Aripirazole group and that was 77.5% in Clozapine group.Significant differences were observed between them（P0.05）.Conclusions： Aripiprazole is an effective and safe drug in the treatment of chronic schizophrenia.Its＇ side effects were fewer.