阿立哌唑维持治疗精神分裂症2年随访研究

Follow-up comparison study of Aripiprazole in maintenance treatment of schizophrenia

目的:评价阿立哌唑在维持治疗精神分裂症中的效果。方法:将66例精神分裂症患者随即分为两组,研究组用阿立哌唑治疗,对照组用利培酮治疗。共观察24个月,并在入组时和治疗后6、12、18、24月末行阳性和阴性症状量表(PANSS)评定,观察两组患者维持治疗期间的复发情况,采用社会功能缺陷筛查量表(SDSS)评定社会功能,不良反应量表(TESS)评定药物不良反应。结果:研究组服药依从率78.8%,平均用药时间(532.5±128.1)天,复发率24.2%;对照组服药依从率69.7%,平均用药时间(477.6±132.2)天,复发率36.4%,两组比较差异无显著性。SDSS评价示研究组社会功能恢复优于对照组。TESS评价示不良反应相当(P>0.05)。结论:阿立哌唑维持治疗精神分裂症疗效显著,不良反应小,且可有效改善患者的社会功能。

Objective：To explore the clinical effect of Aripiprazole in maintenance treatment of schizophrenia.Methods：A total of 66 patients with schizophrenia in maintenance treatment were randomly divided into study group with Aripiprazole and control group with Risperidone.The period study was 24 months.The efficacy and side effects were rated with PANSS,SDSS and TESS before treatment and in the end of 6,12,18,24 months.Results： In study group medication compliance rate was 78.8%,average use time was（532.5±128.1）days,the recurrence rate was 24.2%;In control group,medication compliance rate was 69.7%,average use time was（477.6±132.2） days,the recurrence rate was 36.4%.There was no significant difference between two groups.The scores of PANSS exhibit that in study group the relapse rate is lower than the control group in the end of 18 and 24 months.（P0.05）,medication compliance rates is better than the control group（P0.05） the average drug time is longer than the control group（P0.05）.The scores of SDSS exhibit that in study group the restoration of social function than the control group.TESS show that there was no significant difference between two groups on side effects except weight gain（P0.05）.Conclusions： Aripiprazole is safe and effective with slight side effects in maintenance treatment of schizophrenia and should improve social functions of patients.