阿立哌唑与利培酮治疗精神分裂症的临床对照研究

Aripiprazole and risperidone in the treatment of schizophrenia in clinical controlled study

目的:比较阿立哌唑与利培酮治疗精神分裂症的疗效和安全性。方法:将64例精神分裂症患者随机分为两组,阿立哌唑组32例,利培酮组32例,分别治疗8周;以阴性、阳性症状量表(PANSS)和治疗中出现的症状量表(TESS)分别评定疗效和不良反应。结果:在治疗第8周末,两组的显效率分别为68.8%及65.7%(P>0.05),有效率分别为90.7%及93.8%(P>0.05),两组治疗前后的PANSS总分同组比较有显著性差异(P<0.01),两组间比较无显著性差异(P>0.05)。结论:阿立哌唑与利培酮对精神分裂症的治疗疗效相当,阿立哌唑的不良反应少于利培酮。

Objective：To compare the aripiprazole and risperidone in the treatment of schizophrenia and safety.Methods：64 patients with schizophrenia were randomly divided into two groups,group of 32 cases of aripiprazole,risperidone group of 32 patients were treated for 8 weeks;to negative and positive symptom scale（PANSS） and treatment of the symptoms Scale（TESS） were assessed the efficacy and adverse reactions.Results： The results in the treatment of the first 8 weeks,the two groups were markedly effective rate was 68.8% and 65.7%（P 0.05）,the effective rates were 90.7% and 93.8%（P0.05）,the two groups before and after treatment of the PANSS total score in the same group There was a significant difference（P0.01）,between the two groups showed no significant difference（P0.05）.Conclusions： Aripiprazole and risperidone for schizophrenia therapy equivalent aripiprazole side effects less than risperidone.