急性冠脉综合征患者血清总胆红素、尿酸及纤维蛋白原水平与冠脉病变积分的相关性分析

The relationship between total bilirubin,uric acid,fibrinogen and the severity of coronary artery disease in patients with acute coronary syndrome

目的:探讨急性冠脉综合征患者(ACS)血清总胆红素(TBIL)、尿酸(UA)及纤维蛋白原(FIB)含量变化及其与冠脉病变程度(冠脉病变积分)的相关性。方法:将232例ACS患者分为2组,其中急性心肌梗死(AMI)患者102例,不稳定性心绞痛(UAP)患者130例,同时选择冠状动脉造影(CAG)正常患者50例作为对照组,分别测定各组TBIL、UA及FIB的含量,并与冠脉病变积分做相关性分析。结果:ACS患者UA及FIB含量均高于对照组,而TBIL含量低于对照组(P<0.01)。UA、FIB与冠脉病变积分呈正相关,TBIL与冠脉病变积分呈负相关。结论:UA和FIB的升高及TBIL的降低与ACS发生和冠脉病变的严重程度有一定的关系。

Objective： To investigate the relationship between total bilirubin （TBIL）, uric acid （UA）, fibrinogen （FIB） and the severity of coronary artery disease in patients with acute coronary syndrome（ACS）. Methods： 232 patients with ACS were divided into two groups： group A patients with acute myocardial infarction （n=102）, group B patients with unstable angina pectoris（n=130）.50 normal subjects served as control. The levels of TBIL, UA and FIB were determined. Results： The levels of UA and FIB in patients with ACS were higher than those of control group, the level of TBIL in patients with ACS were lower than those of control group （P〈0.01）. The level of UA and FIB positively and the level of TBIL negatively related with the severity of coronary artery disease （P〈0.05）. Conclusion： The levels of elevated UA and FIB, reduced TBIL are closely related with ACS and the severity of coronary artery disease.