原发性高血压早期肾损害检测血清γ-痕迹蛋白、尿NAG与尿微量白蛋白的临床意义

The Clinical Significance of Serum γ-trace Protein、Urine NAG and Microalbuminuria Tested in Primary Hypertension with Early Renal Damage

目的:探讨血清γ-痕迹蛋白、尿N-乙酰-B-D-氨基葡萄糖苷酶(NAG)与尿微量白蛋白检测对原发性高血压早期肾损害的临床意义。方法:将86例高血压病患者按有无肾脏损害分为两组,原发性高血压肾损害者48例,单纯性高血压患者38例,同时选择54例健康体检人群作为正常对照组。分别测定血清γ-痕迹蛋白、尿NAG、尿微量白蛋白并对结果进行比较分析。结果:单纯性高血压组以上检测项目结果与正常对照组比较差异无显著性(P>0.05);高血压肾损害组各检测结果与对照组比较差异有显著性(P<0.01)。结论:血清γ-痕迹蛋白、尿NAG与尿微量白蛋白联合检测对原发性高血压早期肾损害的诊断有重要意义。

Objective： To investigate clinical significance of γ-trace protein in serum, urine NAG and mALB in primary hypertension with early renal damage. Methods： 86 patients with primary hypertension were divided into two groups according to whether the kidney was damaged. 48 cases were hypertensive nephropathy, 38 cases were simple hypertension,while 54 healthy people worked as control group. The concentrations of serum γ-trace protein, urinary NAG ,mALB were tested, and the results were compared. Results：There was no significant difference in simple hypertension results for all tested items compared with that of control group, but significant with that of hypertensive renal injury group. Conclusion：The joint detection of γ-trace protein in serum,urine NAG and urinary albumin is important for early diagnosis of essential hypertension which results in renal damage.