医院感染金黄色葡萄球菌的耐药性探讨

Drug resistance in Nosocomial Infections with Staphylococcus aureus

目的探讨医院感染金黄色葡萄球菌(SAU)的耐药现状,为临床医师合理使用抗菌药物提供科学依据。方法对179株SAU的耐药现状进行回顾性调查分析,SAU鉴定采用常规方法进行,药敏试验采用纸片扩散法进行,依据CLSI规则判断结果。结果 SAU对多种抗菌药物均产生了不同程度的耐药性,对糖肽类抗菌药物万古霉素和替考拉宁敏感率为100.0%;耐甲氧西林金黄色葡萄球菌(MRSA)分离率为38.5%。结论应加强医院感染管理,控制耐药菌医院感染的暴发流行。

OBJECTIVE To investigate the drug-resistance of Staphylococcus aureus（SAU） and provide scientific evidence for reasonable application of antibiotics.METHODS Retrospective reviews were performed to analyze the drug-resistance of 179 clinical isolates of SAU.SAU was identified by routine methods.Antibiotic sensitivity testing was performed by K-B method.And drug-resistance results were read according to CLSI.RESULTS SAU had been resistant to the diverse antibiotics in different degree.The rate of drug sensitivity to glycopeptide antibiotics such as vancomycin and teicoplanin was all 100%.The isolating rate of meticillin-resistant S.aureus（MRSA） was 38.5%.CONCLUSION We should strengthen management of nosocomial infections to control outbreak and epidemic of nosocomial infections.