多发原发性大肠癌

Multiple primary colorectal carcinoma.

目的探讨多发原发性大肠癌的临床特点和诊断治疗。方法对１９８３～１９９７年收治的２６例病人进行回顾性分析。结果本组病例占同期收治原发性大肠癌的２２７％（２６／１１４７），同时性多原发癌占１２２％（１４／１１４７），异时性多原发癌占１０５％（１２／１１４７）。同时性癌根治术５年生存率７１４％；异时性癌第一癌根治术后５年生存率８７５％，第二癌根治术后５年生存率５０％。结论应提高对多发原发性大肠癌的认识，对病变行根治性手术。

Objective This study attempts to clarify the clinical features of multiple primary colorectal carcinoma(MPCC).Methods The files of 26 patients admitted from 1983 to 1997 were analyzed retrospectively.Results The incidence of MPCC was 2 27%(26/1147)in all patients with primary colorectal carcinoma.The incidence of synchronous carcinoma(SC)was 1 22%(14/1147)and that of metachronous carcinoma(MC)was 1 05%(12/1147).After radical operation,the 5-year survival rate for SC,MC with the first cancer and MC with the second cancer were 71 4%,87 5% and 50% respectively.Conclusion These results emphasized the importance of careful pre-operative examination,intra-operative exploration and post-operative surveillance.The principle of treatment was radical operation for the patients with MPCC.