小剂量琥珀胆碱在气管插管中的应用

Effectiveness of low-dose succinylcholine in oral intubation

目的研究小剂量琥珀胆碱（Ｓｃｃ）在全麻诱导气管插管中的作用及副作用。方法选择临床３０例ＡＳＡⅠ～Ⅱ级的择期手术病人，在全麻诱导中应用不同剂量（１５ｍｇ／ｋｇ和０５ｍｇ／ｋｇ）的Ｓｃｃ，观察心血管系统、肌松作用、不良反应和并发症的变化。结果小剂量起效晚约２１６分钟，呼吸暂停时间短约２０９分钟，肌松作用及插管条件满意，对心血管系统的影响与大剂量相比无统计学差异，肌颤及术后肌病的发生亦无统计学差异（Ｐ＞００５）。结论与大剂量相比，小剂量也能提供满意的插管条件及充足的插管时间，不良反应及并发症并未相应减轻。

Objective To study the effect and side effect of low-dose succinylcholine in the Intubation of general anaesthesia. Methods 30 patients (ASA grade 12)undergoing general anaesthesia were allocated to receive different dose (0.5 mg/kg and 1.5 mg/kg )succinylcholine .The alteration of cardiovascular system ,muscular relaxation ,adverse reaction and complication were observed. Results Pre-effect time of low-dose is about 2.16 min ,longer than that of large-dose .Duration of apnea is about 2.09 min ,shorter than that of large-dose .Situation of muscular relaxation and intubation condition is good .Effect of cardiovascular system did not differ significantly from that of large-dose (P>005). Conclusion Low-dose succinylcholine can provide satisfactory condition and enough time for intubation ,although the adverse reaction and complication were not diminished correspondingly.