以功能性核磁共振造影初探10Hz调制激光针灸刺激所引发人类大脑皮质的活化现象(英文)

The Preliminary fMRI Investigation of 10 Hz Modulation Laser Acupuncture Induced Cerebral Cortical Activation in Human

使用10 Hz调制的低功率激光针灸刺激探究大脑皮质反应.以功能性核磁共振造影技术探讨当激光针灸刺激左脚涌泉穴(K1)时,大脑可能产生的反应机制.研究发现调制激光针灸所引发显著的大脑活化反应,包括右额叶中央前回、右额叶上回、左额叶中央前回、左顶叶中央后回、左侧下部顶叶、左小脑舌前叶、左海马旁回和左小脑山顶等区域.安慰剂组实验并没有发现在脑部有任何活化反应,大多数反应区域所涉及功能与记忆、注意力及自我意识等有关联.结果显示出调制激光针灸的大脑血液动力学反应,并隐含此反应机制不只是依据传入感觉信息处理,而且还有着随外部刺激的变化而有所改变的血液动力学性质.

The aim of this study is to explore the distinct cerebral activation with 10 Hz-modulated wave （MW） stimulation during low-level laser acupuncture.Functional magnetic resonance imaging （fMRI） studies have been performed to investigate the possible mechanism during laser acupuncture stimulation at the left foot＇s yongquan （K1） acupoint.It was found that the MW stimulation aroused the significant activations within the precentral gyrus of right frontal lobe,the right superior frontal gyrus,the precentral gyrus of left frontal lobe,the postcentral gyrus of left parietal lobe,the left inferior parietal lobule,the cerebellar lingua of left anterior lobe,the left parahippocampal gyrus,and left culmen.However,placebo stimulation did not show any activation.Most activated areas were involved with the functions of memory,attention,and self-consciousness.The results show the cerebral hemodynamic response to the MW laser acupuncture stimulation mode the mechanism of which is not merely information processing based upon afferent sensation,but also the hemodynamic property that may be altered with the change of the external stimulation.