麻黄根提取物对自发性高血压大鼠降压作用的观察

Experimental study on the hypotensive effect of Ephedraroot extracts on the spontaneously hypertensive rats

目的:观察麻黄根提取物表阿夫儿茶精、麻黄酚、豆甾醇-3-O-β-D-吡喃葡萄糖苷、辛酸乙酯对自发性高血压大鼠(spontaneously hypertensive rats,SHR)的降压作用。方法:大鼠随机分为6组,即空白对照组、阳性对照组(复方罗布麻片)、表阿夫儿茶精组、麻黄酚组、豆甾醇-3-O-β-D-吡喃葡萄糖苷组、辛酸乙酯组。给药后检测SHR的收缩压和舒张压。结果:表阿夫儿茶精组、麻黄酚组与空白对照组比较差异有显著性(P<0.05)。表阿夫儿茶精组与阳性对照组比较,二者的收缩压和舒张压差异均无显著性,即表阿夫儿茶精对SHR的降压作用与阳性对照药的药效相当;麻黄酚组与阳性组比较,舒张压差异无显著性,而收缩压差异有显著性(P<0.05),即麻黄酚对SHR舒张压的降压作用与阳性对照药相当,对SHR收缩压的降压作用强于阳性对照药。结论:麻黄根提取物表阿夫儿茶精、麻黄酚具有显著的降压作用,为麻黄根降压的活性成分。

OBJECTIVE To observe the hypotensive effect of the Ephedra root extracts-epiafzelechin,ephedrannin,stigmas- terol-3-O-β-Dglucopyranoside and ethyl caprylate on the spontaneously hypertensive rats （SHR）. METHODS The rats were divided into 6 groups at random, as follows： blank contrast group, positive drug contrast group （Fufang I.uobuma tablet）, epiafzelechin group,ephedrarmin group, stigmasterol -3-O-β-D glucopyranoside group and ethyl caprylate group. The data of systolic pressure and diastolic pressure were examined after the rats were given defferent drugs. RESULTS The rats blood pressure data of the epiafzelechin group and ephedrannin group showed statistically significant difference compared with the blank contrast group. And there were no significant difference between the epiafzelechin group and the positive contrast group, that is, Epiafz- elechin＇s hypotensive effect were correspondent with positive drug on SHR. The diastolic pressure data of ephedrannin group had no significant difference while systolic pressure data were significantly different to those of positive contrast group, that is, the effect on the rat＇s diastolic pressure of ephedrannin were correspondent with positive drug while its effect on the rat＇s systolic pressure was stronger than the positive drug. CONCLUSION Ephedra root extracts-epiafzelechin and ephedrannin,which have significantly hypotensive effect, both are hypotensive active ingredients on SHR.