左卡尼汀提高心脏X综合征患者的运动耐量

Improvement of exercise tolerance by L-carnitine in patients with cardiac syndrome X

目的:以常规治疗为对照,观察左旋卡尼汀对心脏X综合征患者的临床症状和运动耐量的影响。方法:采用前瞻、随机、对照的方法将61例心脏X综合征患者随机分为2组。对照组31例予常规药物治疗。左旋卡尼汀组30例,在常规治疗的基础上加用左旋卡尼汀3.0g静滴治疗,qd,14d。比较治疗前后每周心绞痛发作次数及硝酸甘油消耗量,运动耐量。结果:治疗后2组心绞痛发作次数、硝酸甘油消耗量均减少(P<0.05);左卡尼汀组运动至出现ST段压低1mm所需时间、心绞痛所需时间延长,ST段缺血型下移之和明显减少,运动持续时间显著延长(P<0.05或P<0.01),常规治疗组无明显变化(P>0.05)。结论:左卡尼汀能够显著改善心脏X综合征患者的临床症状和运动耐量,提高患者的生活质量。常规治疗仅有缓解临床症状的作用。

OBJECTIVE To compare the efficacies of L-carnitine on exercise tolerance in patients with cardiac syndrome X. METItODS Sixty-one patients with cardiac syndrome X were divided into two groups by randomized control trial. Patients in the negative control group received conventional treatment （nitroglycerin, 13-receptor blocker, vasodilator） . Patients in the ex- perimental group were subjected to conventional treatment combined with L-carnitine,one time a day,once 3 g. The treatment course was 14 days. Treadmill exercise test was adopted to investigate exercise tolerance before and after the therapy. RESULTS After L-carnitine or conventional treatment, angina peetoris attack frequency and consumption of nitroglycerin weekly were decreased obviously（P〈0. 05） ; the time for inducing angina and i mm ST segment depression, the total exercise time and total ST depression by exercise were improved obviously only in levocarnitine group（P〈0.05. or P〈0. 01 ）. there＇s no changes in ECG during treadmill exercise in group received conventional treatment（P〉0. （15）. CONCLUSION The results showed that L- carnitine could prolong the patients＇ total exercise time, improve their exercise tolerance. The conventional treatment only could relieve the symptoms.