急性坏死性胰腺炎对心肾损伤的影响

Heart and kiddney organ damage in experimental acute necrotizing pancreatitis

目的探讨急性坏死性胰腺炎（ANP）对心肾损伤的影响。方法采用3.5％牛磺胆酸逆行注射胰胆管建立鼠的ANP模型。观察炎性介质内毒素、淀粉酶、磷脂酶A2，白细胞介素（IL－）1、肿瘤坏死因子x（TNFα）的变化和生长抑素的作用。结果ANP可以诱导炎性介质的明显升高，并与心肾损伤的严重程度呈正相关。而生长抑素能抑制ANP的炎性介质过度表达，减轻心肾损伤的程度。结论炎性介质参与了ANP对心肾器官的损伤，生长抑素对ANP的心肾损伤有治疗价值。

Obective To study the heart and kidney organ damage in experimental acute necrotizingpancreatitis (ANP). Methods The roles of innarnmatory mediators (endotoxin, amylase, IL-1 β, IL-6,TNFα,PLA2) were investigated in ANP model established by retrograde injection of 3. 5% sodium taurocholate 2. 5 ml/kg into pancreatic duct, and the efficiency of somatosatin analogene stilamin was also observed.Results ANP could induce the obvious increase of the innarnmatory mediators which was opitively correlatedwith the development of heart and kidney damage. Somatostatin could inhibit the overexpression of inflamatpry mediators and alleviate the risk of heart and kidney organ damage. conclusions Inflammatory mediatorsmight play an important role in ANP ptogression and somatostatin may be the effcient treatment to preventthe development and progtession of heart and kidney damage.