肺癌病人血清中免疫抑制物的研究

An immuno-suppressive factor in the serum of patients with lung cancer

目的探讨肺癌病人免疫功能变化的原因和机理．方法用体外培养的方法观察25例肺癌病人血清对正常淋巴细胞转化的影响，以高效液相凝胶过滤法测定肺癌病人血清中免疫抑制物的分子量。结果肺癌病人血清能显著抑制正常小鼠淋巴细胞转化，其抑制强度与肺癌的TNM分期有正相关关系（P＜0．01），而与肺癌病人的年龄和肺癌的病理类型无关．结论肺癌病人血清中存在免疫抑制物，它的产生与肿瘤的存在和发展有密切的关系．

Objective To investigate the causes and mechanisms of the immunologicalfunction changes in the patients with lung cancer and the effect of the serum from patients with lung cancer on normal lymphocyte proliferation. Methods Lyrnphocyte proliferation was used, and the molecular weight of the serum suppressire factor in patients with lung cancerwas identified by HPLC gel filtration column. Results The patients serutn obviously suppressed normal lymphocyte proliferation in mice. There was a positive correlation between the suppression inducedby the serum and the lung cancer stage (P<0. 01), but the suppression had no relationship to the ageof patients and different pathologic types of lung cancer. The molecular weight of the serum immunesuppressive factor was between 150 kD to 426 kD. Couclusion The generation of the suppressive factor in the serum of patients with lung cancer was closely correlated with the existence and developmentof the lung cancer.