高血糖对急性脊髓损伤后果的影响

Effects of hyperglycemia on neurologic outcome after acute spinal cord injury

目的探讨给予高渗糖对急性脊髓损伤后神经学功能恢复的影响。方法将16只健康禁食的大白兔随机分为两组，采用Alien’s脊髓损伤模型，在脊髓损伤前一组动物接受50％高渗糖0．5g／kg体重（处理组），另一组采用等容量生理盐水对照（对照组），脊防损伤前后采股动脉血测定血糖并于损伤后3天进行神经学评分。结果处理组与对照组相比，血糖水平显著增高（P＜0．04），72小时后的神经功能评分也明显不如对照组（P＜0．01）。结论急性脊髓损伤期间的高血糖可加重脊髓继发性损伤。

Objective To investigate the influence of dextrose administration on neurologic outcome after acute spinal cord injury. Methods Sixteen fasted rabbits were randomly divided into twogroups (n=8 in each). The Allen's model of spinal cord injury of rabbit was applied. The animals received intravenous dextrose 0. 5 g/kg body weight (treatment group) and placebo (control group) before acute spinal cord injury respectively. Plasma glucose level was measured before and after spinalcord injury. Neurologic outcomes were observed 3 days after spinal cord injury. Results Plasma glucose level was significantly increased in treatment group as compared with control group (P<0. 04).Neurologic outcome was poorer (P <0. 01 ) at 72 h in the animals that had received dextrose. Conclusion The increased plasma glucose may result in a worsened neurologic outcome after acute spinal cordinjury.