雄激素对结石诱导雄鼠肾内结晶体的影响

Effect of sex hormone on the stone-inducedu rolithiasis in male rat

目的探讨雌激素对尿石症患者的影响。方法用0．5％乙二醇诱导结石形成，建立4组动物实验雄鼠模型。A组：去势结石组；B组：去势+皮下注射睾丸酮（3mg／d）结石组;C组：结石对照组；D组；正常对照组（标准无结石饮食）。4组雄鼠饲养4周后同时宰杀，分别测定和比较他们血清Testo、FSH、LH、E2、PRL、Prog，肾内晶体沉和部位及程度。结果A、B、C各组间差异均有显著性（P＜O．001）。结论雄性激素对尿石症有一定影响。

Objective To investigate testosterone in the pathogenesis of urolithiasis. MethodsForty adult Wistar rnale rats were equally divided into 4 groups. The rats in group A (castrated), groupB (castrated plus subcutaneous injection of Testo 3 mg/day) and group C (untreated, served stone control) were fed with 0. 5 % ethylene glycol (EG) lithogenic diet for 4 weeks. The rats in group D was leftuntreated and served as normal controls. The stone and crystal deposits in all groups were examined byinfrared spectrometer respectively. Serum Testo, FSH, LH, Prog, PRL and E2 were determined. Result The stone crystal deposits among A, B, C were different from each other (P <0. 001 ). Conclusion Testo had a certain influence on urolithiasis.