皮下埋植吡喹酮缓释剂控制家犬细粒棘球绦虫感染的实验研究

EXPERIMENTAL INVESTIGATION ON THE CONTROL OF ECHINOCOCCUS GRANULOSUS INFECTION IN DOGS BY SUBCUTANEOUSLY PLANTATION WITH A SLOW RELEASED PREPARATION OF PRAZIQUANTEL

家犬皮下埋植吡喹酮缓释剂的剂量与驱虫效果相关。用50mg／kg剂量在埋植后4个月以细粒棘粒蚴原头节进行攻击可保护家犬不受感染。3只家犬埋植剂量为36．36、4444和66．66mg／kg吡喹酮，3个月药物释放率各为76.7％、65.8％和56．1％。血液吡喹酮浓度在埋植后10天至3个月维持在0．8974～3．6849μg／ml之间。50mg／kg吡喹酮剂量对植药犬的肝肾功能无明显影响。

The dehelminthic efficacy of the slow released preparation subcutaneously planted in dogs correlated withdoses of praziquantel. With the dose of 5Omg/kg of praziquantel may prevent the dogs from challenging infection with proto-scolices of E. granulosus. Three dogs planted with 36. 36mg/kg, 44. 44mg/kg and 66. 66mg/kg of praziquantel the drug releaserate were 76' 7%, 65. 8% and 56. l % respectively in 3 months and the concentration of praziquatel in serum of these dogswere sustained within O. 8974~3. 6849 pg/ml. By examination the functions of the liver and kidney have not resulted any ab-normalities in the dogs of drug plantd.