人体内微量元素与亚硝胺的合成量的关系

Relation of Trace Elements with Synthesize of N nitroproline in Human Body

随机选取食管癌高低发区健康人６０例，服用脯氨酸，采集晨尿，测定１３种微量元素和亚硝基脯氨酸的含量，进行统计学分析：各指标的均值ｔ检验、等级相关、剂量－效应及Ｎ－亚硝基脯氨酸相对生成率的Ｕ检验．结果表明：与Ｎ－亚硝基脯氨酸合成量呈正相关的元素是铍、铬、镍，呈负相关的有硒、钼、砷（Ｐ＜０．０５～０．０１）．

healthy adult were randomly selected from the districts of high and low incidence of Esophageal cancer. They were asked to take proline and the 13 trace elements(TE) and N nitroproline (NPRO) in their urine of the next morning were determined. The contents of TE and NPRO were used to perform statistical analysis:t test of value of variable, Rank correlation, Dosage effect, and U test of relativity NPRO and TE. It was suggested that there is a negative correlation between contents of As, Mo, Se and NPRO synthesis in body which the positive one is for Be,Cr and Ni.