中国鲎鲎素T-1抗人早幼粒白血病HL-60细胞活性研究

Study on Antitumor Activity of Tachypesin I against Human Promyelocytic Leukemia Cell Line HL 60 from Hemocyte of Horseshoe Crab

利用从中国鲎血细胞中提取的鲎素Ｔ－１作抗肿瘤活性实验．结果表明，鲎素Ｔ－１在体外对人早幼粒白血病ＨＬ－６０细胞的增殖有明显抑制作用．急性毒理实验显示，鲎素Ｔ－１对正常活体毒性较小，可用于活体实验．荷瘤裸鼠实验统计，鲎素Ｔ－１对肿瘤抑制率达４２．３％．

The antitumor activity of tachyplesin I(T 1) extracted from the hemocytes of horseshoe crab Tachypleus tridentatus for human promyelocytic leukemia cells line HL 60 has been studied. It was demonstrated that tachyplesin I had the remarkable inhibitory activity on proliferation of HL 60 cells in vitro experiment. The result from acute toxicological assay showed that tachyplesin I only had a little toxicity and could be used in intravital research. The rate of tumorous suppression of tachyplesin I reached to 42.3% on HL 60 cells.