2181例头孢曲松钠不良反应报告分析

Analysis of 2 181 ADR reports of ceftriaxone sodium

目的分析我省2009年收集到的头孢曲松钠不良反应发生的特点,为临床安全合理用药提供参考。方法采用回顾性研究方法,对广东省药品不良反应（ADR）监测中心2009年接收的由头孢曲松钠所致的2181份ADR报告进行综合分析。结果头孢曲松钠是引起我省ADR频率最高的药品,其ADR涉及系统最多的为皮肤及其附件损害（1563例）,其次为全身性损害（389例）、循环系统损害（162例）;主要ADR表现为皮疹、瘙痒、过敏样反应;主要给药途径为静脉滴注（92.11%）。结论应重视头孢曲松钠引起ADR的各种因素,采取有效措施预防或治疗ADR。

Objective To analyze the characteristics of adverse drug reactions （ADRs） of ceftriaxone sodium collected in Guangdong Province in 2009 to provide references for rational and safe medication in clinical practice.Methods 2 181 ADR reports of ceftriaxone sodium collected by Guangdong ADR Monitoring Center in 2009 were analyzed comprehensively by retrospective study methods.Results Ceftriaxone sodium was the drug causing ADR the most frequently in Guangdong Province,ADRs of ceftriaxone sodium were mainly skin and skin appendage harm （1 563 cases）,systemic harm （389 cases）,and circulatory system damage （162 cases）; The clinical manifestations of ADR were mainly rash,pruritus,anaphylactoid reaction; Intravenous dripping was the main route of administration （92.11%）.Conclusion Attention should be paid to the multiple factors causing ADRs of ceftriaxone sodium,and measures should be taken to prevent and control the ADRs.