氨溴特罗治疗儿童下呼吸道感染疗效观察

Observation of therapeutic efficacy of Ambrocol aral solution for lower respiratory tract infection in children

目的 观察氨溴特罗口服液治疗儿童下呼吸道感染的疗效和不良反应. 方法 160例下呼吸道感染患儿按入院单双号随机分为两组,在常规治疗的基础上,治疗组给予口服氨溴特罗口服液,对照组给予口服盐酸氨溴索糖浆,观察两组的临床治疗效果和不良反应发生情况. 结果 治疗组显效62例、有效12例、无效6例、总有效率92.5%,对照组分别为50例、15例、81.3%,两组总有效率差异有统计学意义（χ^2=4.44,P＜0.05）;治疗组咳嗽消失时间（4.5±1.4）d、咳痰困难消失时间（3.1±1.2）d、哮鸣音消失时间（2.9±1.2）d,与对照组的（5.4±1.5）d、（3.5±1.2）d、（3.7±1.4）d相比较,差异均有统计学意义（t=3.930、2.105、7.767,均P＜0.05）. 结论 氨溴特罗口服液是适合各年龄段儿童的止咳祛痰药物,疗效高,安全性好,可提高儿童下呼吸道感染临床效果.

Objective To observe the effect and adverse reaction of ambrocol oral solution on treatment of children with lower respiratory tract infection. Methods 160 children hospitalized with lower respiratory tract infection in children according to odd and even numbers were randomly divided into two groups on the basis of conventional therapy,the treatment group were given oral ambrocol oral solution,the control group treated with oral ambroxol hydrochloride syrup.The clinical efficacy and adverse reaction were observed. Results 62 cases were excellent,effective in12 cases,not effective in 6 cases,total effective rate 92.5 %,and the control group 50 cases,15 cases,81.3 % compared to the total effective rate between the two groups was statistically significant（χ^2=4.44,P〈0.05）; treatment group cough disappearance time（4.5 ± 1.4）d,expectoration difficulties disappear time（3.1 ± 1.2）d,wheeze disappearance time（2.9 ± 1.2）d,and the control group（5.4 ± 1.5）d,（3.5 ± 1.2）d,（3.7 ± 1.4）d phase by comparison,the differences were statistically significant（t=3.930,2.105,7.767,all P 〈0.05）. Conclusion Ambrocol oral solution is appropriate for children of all ages expectorant cough medicine,high efficacy ,safety ,and can improve the clinical effects of lower respiratory tract infection.