二甲双胍联合运动疗法对糖耐量减低患者的干预效果

Observation of effect of metformin and exercise therapy for IGT.

目的 观察二甲双胍联合运动疗法对糖耐量减低（IGT）患者的干预效果. 方法 86例IGT患者采用二甲双胍联合运动疗法治疗,观察治疗前后空腹血糖及口服75 g葡萄糖2 h后血糖水平、体重指数变化及IGT的转归情况. 结果 经干预后,患者的空腹血糖水平、口服75 g葡萄糖2 b后血糖水平、体重指数均明显下降（均P＜0.01）,72例（83.7%）患者糖耐量恢复正常,14例（16.3%）患者仍维持IGT阶段（均述未能坚持运动,且未加以饮食控制）,无一例转为糖尿病. 结论 二甲双胍联合运动疗法干预IGT效果良好.

Objective To observe the effect of metformin and exercise therapy for IGT. Methods 86 patients with IGT were given metformin and exercise therapy,the range of glucose,BMI and symptoms improvement were observed before and after the therapy. Results After 6 months therapy,the fasting blood glucose and 2 h after oral administration of 75 g glucose levels were significantly reduced（P〈0.01）,BMI reduced（P〈0.05）.72 cases （83.7%）were back to normal glucose tolerance,14 cases maintained IGT（those unable to adhere to exercise and no diet controlled）,0 case became DM. Conclusion Metformin and exercise therapy had good efficacy in curing IGT.