不同时期恙虫病并发肝损害情况比较

Compare the characteristics of liver damage in tsutsugamushi disease during different periods

目的 比较不同时期恙虫病并发肝损害情况. 方法 1997年1月至2000年12月收治恙虫病患者56例,并发肝损害21例（A组）;2006年1月至2009年12月收治恙虫病患者80例,并发肝损害47例（B组）,对两组患者肝功能损害情况进行回顾性对比分析. 结果 A组平均年龄（41.1±14.7）岁明显低于B组的（52.9±15.5）岁（t=3.014,P＜0.01）;A组肝、脾肿大发生率明显高于B组（χ^2=4.675、6.254,均P＜0.05）,B组的纳差、腹胀、黄疸等发生率明显高于A组（均P＜0.05）,B组肝功能各项指标明显高于A组（均P＜0.05）. 结论 近年来恙虫病发病率有增高趋势,且并发肝功能损害症状加重.

Objective To compare the characteristics of liver damage in tsutsugamushi disease during different periods. Methods Group A contained 56 cases of tsutsugamushi disease admitted from January 1997 to December 2000,of which 21 cases were complicated by liver damage,while group B contained 80 cased of it admitted from January 2006 to December 2009,including 47 cases complicated by liver damage.Comparative analysis were conducted retrospectively for two groups in terms of liver damage. Results The average age of group A（41.1 ± 14.7）years was significantly lower than that of group B（52.9 ± 15.5）years（t=3.014,P 〈0.01）; The incidences of hepatomegaly and splenomegaly in group A were significantly higher than group B（χ^2=4.675、6.254,both P 〈0.05）whereas group B had significantly higher incidences of lack of appetite,abdominal distension and jaundice（all P 〈0.05）;The values of various liver function in Group B were significantly higher than group A（all P 〈0.05）. Conclusion The incidence of tsutsugamushi disease is increasing in recent years and the liver damage is becoming more severe.