相关凋亡基因在多发性骨髓瘤发病中作用的研究进展

The Role of related apoptosis gene in the pathogenesis of multiple myeloma

多发性骨髓瘤（MM）是浆细胞克隆性增生的恶性肿瘤，是一种低增殖性、低凋亡活性的分子克隆性疾病，这一特点提示凋亡抑制可能在其发病中发挥了重要的作用。因此，研究MM发病过程中相关的促凋亡基因（蛋白）和抑凋亡基因（蛋白）以及它们之间的相关性，将为MM的分子靶向治疗提供新的策略。

Multiple myeloma （MM） is a clonal plasma cell malignancy, a low proliferative and low apoptotic activity molecular cloning of a disease, which indicates that apoptosis inhibition may play an important role in the pathogenesis of MM. Therefore, the study of MM pathogenesis-related promoting apoptosis genes/proteins and inhibiting of apoptosis genes/proteins, as well as the correlation between them provides a new strategy for molecular targeted therapy.