摘要
目的：探讨X波段脉冲波孕期照射致大鼠子代脑功能发育障碍的神经电生理机制。方法：以功率密度5～20mW／cm^2的脉冲微波对孕鼠进行孕期慢性辐照（孕6～16日隔日一次，每次20分钟），研究成年子鼠皮层体感诱发电位（SEP）和事件相关电位（ERP）变化。结果：与对照组相比．各辐射组仔鼠SEP各波峰潜伏期和振幅均无差异，但在10、20mw／cm^2功率组则出现仔鼠ERP的峰潜伏期明显延长，且其变化与前期行为学实验结果相一致。ERP波幅改变无规律性，5mW／cm^2剂量无上述作用。结论：反映认知功能的ERP较反应传导功能的SEP更适用于脑高级功能研究，ERP异常与脉冲微波导致的胎鼠脑功能发育障碍有联系。
AIM: To discuss the neuroelectrophysiological mechanisms of brain function development damage inoffsprings of rats who have been exposed to X -band microwave pulses during pregnancy. Method: After chron-ic exposure of microwave with the power densities of 5- 20 mW/cm^2 during pregnancy (for 30 minutes every oth-er day from the 6th to 16th day of gestation), Somatosensory (SEP) and Event -related Potential (ERP) in ma-tured off springs were studied. Results: There is no difference between control group and all the radiation groupsin both latencies and amplitudes of all SEP waves in rat off springs, but in 10 - 20 mW/cm^2, prolongation ofpeak latencies of ERP were evident and it correlated well with the former behaviral test results. Amplitudes ofERP didn't change and dosage of 5 mW/cm^2 has 110 effect mentioned above. Conclusions: ERP which stands forcognitive functions is more applicable than SEP which stands for conductive functions in the study of higher brainfunctions and there is relation between abnormality of ERP and impairment of brain function development of ratfetus induced by radiation of microwave pulses.
出处
《中国医学物理学杂志》
CSCD
1999年第3期172-174,共3页
Chinese Journal of Medical Physics
基金
国家自然科学基金!39600035
