IUD对生殖道局部TNF—α和IL—2浓度的影响

The effect of intrauterine device on the levels of tumor necrosis factor - α and interleukin - 2 in local genital tract.

采用酶联免疫吸附法测定43例正常育龄妇女宫颈粘液的肿瘤坏死因子-α(TNF—α)和白细胞介素-2(IL-2)浓度,探讨宫内节育器对生殖道局部免疫系统的作用。其中27例妇女放置宫内节育器,16例未置器。结果:置器者宫颈粘液TNF-α浓度显著高于未置器者(P<0.01)。放置V型带铜节育器(VCu200)组宫颈粘液TNF-α浓度比不锈钢金属环组有增高的趋势。宫颈粘液IL—2浓度在置器组与未置器组、VCu200组与不锈钢金属环组之间均未见明显差异。置不锈钢金属环后经血量增加与宫颈粘液TNF—α和IL—2浓度无相关性。放置宫内节育器后子宫局部TNF—α浓度的增高可能是宫内节育器避孕机理之一。

Objective To study the effect of intrauterine device (IUD) on immune system of local genital tract. Method The concentrations of tumor necrosis factor- α( TNF - α) and interleukin - 2 (IL - 2) in cervical mucus were determined by enzyme linked immunosor-bent assay(ELISA)in 43 health women. Results The levels of TNF - α in cervical mucus significantly increased in women with IUD as compared with women without IUD(P<0.01). The concentrations of TNF- α had a tendency to be higher in VCu200IUD group than in stainless steel ring group. The levels of IL - 2 in cervical mucus have no siginficant difference between IUD group and without IUD group, and between stainless steel ring group and VCu200 group. The menstruation blood loss after insertion of stainless steel ring seemed to be no any association with the concentrations of TNF - α and IL - 2. Conclusion The increase of TNF - α in reproductive tract after insertion of IUD probably is one of the contraceptive mechanisms of IUD.