沪191麻疹疫苗免疫持久性和影响因素的评价

Sero epidemiological effects and influence factor of primary immunization with measles vaccine(live Hu 191)

１９９１～１９９８年，我们对荆州区川店镇５０３名６～１５月龄儿童进行了现行沪１９１麻疹疫苗血清流行病学效果观察，结果表明，初次免疫后１个月麻疹ＩｇＧ抗体阳转率为９１６５％，ＧＭＴ为１∶２６６７４，达保护滴度者比例为４６５％。随着时间的推移，第４年上述指标迅速下降到４６８６％、１∶１２７４和１８５％，第６年时低至２９４３％、１∶４８９和１３６％。０２ｍｌ、０３ｍｌ和０５ｍｌ麻疹疫苗组的近期和远期效果是类似的，初免后１个月时ＩｇＧ滴度越高，其免疫持久性越好；初免月龄是影响麻苗免疫效果的主要原因，６月龄初免组的免疫效果明显低于≥８月龄组。结果提示麻苗８月龄初免是可行的。

A study of the sero epidemiological effects of immunization with current measles vaccine (live Hu 191)among 503 children aged 6 to 15 months,were conducted in Jingzhou,Hubei province,from 1991 to 1998.The results showed that the positive conversion rate of measles IgG was 91.65%,GMT was 1∶266.74 and its ratio reaching protecitve titer was 46.5% at 1 month after basic immunization.As time gose on,above mentioned indexes reduced rapidly to 46.86%,1∶12.74 and 1.85% respectively in the 4th year,to 29.43%,1∶4.89 and 1.36% in the 6th year.Short term and long term efficacy of 0.2 ml,0.3 ml and 0.5 ml measles vaccine were similar.The higher IgG titre was at 1 month after basic immunization,the better immune endurance was.The age for basic immunization was a main factor influencing immune response to measles vaccine.Immune efficacy of 6 months olds group by basic immunization was significantly lower than those of ≥8 months olds group.The results indicated it is practicable that infant aged 8 months be vaccinated with measles vaccine in China.