银杏达莫注射液治疗糖尿病远端对称性神经病变的临床研究

Clinical Study of Yinxing Damo Injection for Distal Symmetrical Polyneuropathy in Diabetic Patients

目的:观察银杏达莫注射液治疗糖尿病远端对称性神经病变的疗效及安全性。方法:84例糖尿病远端对称性神经病变患者,随机分为观察组和对照组,各42例。观察组应用银杏达莫注射液20 mL静脉滴注,qd;对照组应用复方丹参注射液40 mL静脉滴注,qd。2组疗程均为2周。比较2组治疗前后症状、体征、神经传导速度的变化及不良反应。结果:治疗后,2组症状、体征明显改善,神经功能缺损评分明显降低,观察组总有效率明显高于对照组,差异有统计学意义(P<0.05)。治疗后观察组感觉及运动神经传导速度明显高于对照组,差异有统计学意义(P<0.05)。2组治疗过程中均未见肝肾功能异常。结论:银杏达莫注射液治疗糖尿病远端对称性神经病变的疗效显著,且安全性良好。

OBJECTIVE：To observe the clinical efficacy and safety of Yinxing damo injection for distal symmetrical polyneuropathy（DSPN）in diabetic patients.METHODS：84 diabetic patients with DSPN were randomly divided into observation group and control group（n=42.） Observation group were given intravenous administration of Yinxing damo injection 20 mL once a day for 2 weeks.Control group were given intravenous administration of Dansen injection 40 mL once a day for 2 weeks.Clinical symptoms,vital signs,nerve conduction velocity and ADR before and after treatment were compared between 2 groups.RESULTS：After 2 weeks of treatment,symptoms and vital signs of 2 groups were significantly improved,and the neurological impairment score was obviously decreased.The total effective rate of observation group was much higher than control group,the difference had statistical significance（P0.05.） Sensory nerve conduction velocity and motor nerve conduction velocity in observation group were much higher than control group after treatment,the difference had statistical significance（P0.05.） No liver and renal dysfunction was found in 2 groups.CONCLUSION：Yinxing damo injection is effective and safe for DSPN in diabetic patients.