期刊文献+

依帕司他联合灯盏花素治疗2型糖尿病周围神经病变的疗效观察

Efficacy Observation of Epalrestat Combined with Breviscapine in the Treatment of Type 2 Diabetic Peripheral Neuropathy
原文传递
导出
摘要 目的:观察依帕司他联合灯盏花素注射液治疗2型糖尿病周围神经病变的临床疗效。方法:选择2型糖尿病周围神经病变患者48例,均给予灯盏花素注射液40 mg静脉滴注,qd;依帕司他50 mg,口服t,id。连用4周。观察患者治疗前、后神经系统症状及体征变化,并测定治疗前、后患者四肢的神经传导速度,膝、跟腱反射以及肝肾功能等。结果:依帕司他联合灯盏花素注射液治疗后,患者神经系统症状及体征变化均明显好转,各神经传导速度与治疗前比较均有显著性差异(P<0.05)。治疗过程中2例患者出现眩晕、心悸,1例患者出现恶心、上腹部饱胀,均未停药,1~3 d后缓解,其余患者未见其他明显不良反应。治疗后肝肾功能无明显变化。结论:依帕司他联合灯盏花素注射液治疗2型糖尿病周围神经病变安全、有效。 OBJECTIVE:To observe the clinical efficacy of epalrestat combined with Breviscapine injection in the treatment of type 2 diabetic peripheral neuropathy.METHODS:48 patients with type 2 diabetes complicating with peripheral neuropathy were all given Breviscapine injection 40 mg once a day by intravenous drip and oral dose of epalrestat 50 mg three times a day for 4 weeks.The changes of symptoms and signs of nerve system were observed before and after treatment,and nerve conductive velocity,knee jerk and achilles tendon reflex,liverkidney function were detected too.RESULTS:After treatment,the symptoms and signs of nerve system were obviously improved.There was significant difference in nerve conductive velocity before and after treatment(P0.05.) During the period of treatment,2 patients suffered from dizziness and palpitation and 1 patient nausea and fullness of upper abdomen.They neither stop taking medicine and the symptoms were relieved after 1~3 days.ADR wasnt’ found in other patients.After treatment liverkidney function wasnt’ improved obviously.CONCLUSION:Epalrestat and Breviscapine injection are safe and effective in the treatment of type 2 diabetic peripheral neuropathy.
作者 王曦 王剑虹
机构地区 贵州省遵义医院
出处 《中国药房》 CAS CSCD 北大核心 2010年第36期3415-3416,共2页 China Pharmacy
关键词 糖尿病 周围神经病变 灯盏花素 依帕司他 Diabetes Peripheral neuropathy Breviscapine Epalrestat
  • 相关文献

参考文献4

二级参考文献39

  • 1杨慧,梁传余,郑虹,秦学玲.手术治疗周围性面瘫51例[J].临床耳鼻咽喉科杂志,2005,19(16):740-741. 被引量:11
  • 2罗小平,范海斌,汪洋.灯盏花素合用脑复素治疗原发性高血压并发腔隙性脑梗死[J].实用中西医结合临床,2007,7(3):11-12. 被引量:4
  • 3Holland N J, Weiner GM. Recent developments in Bell's palsy[J]. BMJ, 2004,329(7 474) : 1 103.
  • 4Quant EC, Jeste SS, Muni RH, et al. The benefits of steroids versus steroids plus antivirals for treatment of Bell's palsy: a meta-analysis[J]. BMJ, 2009,339 : b3 354.
  • 5Salinas RA, Alvarez G, Ferreira J. WITHDRAWN: Corticosteroids for Bell's palsy (idiopathic facial paralysis)[J]. Cochrane Database Syst Rev, 2004,15 (2) : CD 001 942.
  • 6Madhok V, Falk G, Fahey T, et al. Prescribe prednisolone alone for Bell's palsy diagnosed within 72 hours of symptom onset[J]. BMJ, 2009,338: b255.
  • 7LIN D, LOBELL S, JEWELL A,et al. Differential phosphorylation of connexin46 and connexin50 by H2O2 activation of protein kinase Cγ[J]. Mol Vis ,2004 ,10 :688 -695.
  • 8AGARWAL R,CHASE SD. Rapid,fluorimetric-liquid chromatographic determination of malondialdehyde in biological samples [J]. J Chromatogr B Analyt Technol Biomed Life Sci,2002,775(1):121 -126.
  • 9HA TS,SONG CJ,LEE JH. Effects of advanced glycosylation end products on perlecan core protein of glomerular epithelium [ J]. Pediatric nephrology,2004,19( 11 ) :1219 - 1224.
  • 10DAS B, SRIVASTAVA SK. Purification and properties of aldose reductase and aldehyde reductase II from human erythrocyte [ J ]. Arch Biochem Biophys, 1985,238 (2) :670 - 679.

共引文献94

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部