子宫内膜异位症恶变预测及早期诊断

Prediction and early diagnosis of malignant transformation of endometriosis

子宫内膜异位症(内异症)恶变的预测及早期诊断具有重要临床价值。病理诊断中,非典型内异症为恶变前病理改变,病程长、高龄、雌激素、达那唑、月经频发及量多、二英等均为内异症恶变的高危因素。当内异症囊肿迅速增大、疼痛规律改变、CA125>200kU/L、影像检查见囊内乳头等均提示恶变可能。分子机制研究将为内异症恶变的主要研究方向。

It was of great clinic value to predict and earlier diagnose the malignant transformation of the endometriosis （EMs）. The atypical EMs was the precancerous lesions in the pathological diagnosis of the malignant transformation of the EMs. Longer course of disease, older, higher estrogen level, danazol, polymenorrhea and dioxin were all the high risk fac- tors for the malignant transformation of the EMs. When the size of the ectopie cyst increased, or the rhythm of pain changed, or the level of the CA125 was over 200 kU/L, or papillaries were showed in the cyst during the image examination the malignant transformation of EMs must be alerted. The study on the molecular mechanism will become the main research directions for the malignant transformation of the EMs.